mcp-reactome

Name: Reactome
Author: pipeworx-io

Reactome MCP — open biological pathway knowledge-base.

Part of Pipeworx — an MCP gateway connecting AI agents to 673+ live data sources.

Tools

Tool	Description
`search`	Search across all Reactome objects.
`pathway`	Full pathway record by stable id (e.g. R-HSA-68886).
`participants`	Entity participants of a pathway.
`pathways_for_entity`	Pathways containing an entity, looked up by external resource id (e.g. UniProt accession).
`orthologous_events`	Orthologous pathways/reactions in another species.

Add to your MCP client (Claude Desktop, Cursor, Windsurf, etc.):

{
  "mcpServers": {
    "reactome": {
      "url": "https://gateway.pipeworx.io/reactome/mcp"
    }
  }
}

Or connect to the full Pipeworx gateway for access to all 673+ data sources:

{
  "mcpServers": {
    "pipeworx": {
      "url": "https://gateway.pipeworx.io/mcp"
    }
  }
}

Instead of calling tools directly, you can ask questions in plain English:

ask_pipeworx({ question: "your question about Reactome data" })

The gateway picks the right tool and fills the arguments automatically.

MIT