Roots by Benda — Pharmaceutical & Bioequivalence Intelligence MCP Server

Drug safety, interactions, adverse events, and regulatory data in one MCP. Check any drug or active ingredient against DrugBank, WHO Essential Medicines, FDA FAERS adverse events, drug-drug interactions, Australian TGA ARTG, FDA NDI notifications, and ChEMBL bioactivity — all source-linked and free.

Equivalent data through commercial platforms (Lexicomp, Micromedex, DrugBank Pro) costs $20,000+/year. This MCP is free.

Live endpoint: https://pharma-mcp-server.rootsbybenda.workers.dev/mcp SSE fallback: https://pharma-mcp-server.rootsbybenda.workers.dev/sse

Tools

check_drug

Look up a drug, medicine, active ingredient, or CAS number across DrugBank, WHO Essential Medicines, Australian TGA ARTG, and FDA NDI notifications. Returns identifiers, targets, schedules, dosage forms, indications, and regulatory records.

query: "ibuprofen"
→ DrugBank: Ibuprofen (DB01050), CAS 15687-27-1, approved/investigational
  Targets: Prostaglandin G/H synthase 1 & 2, PPAR-gamma, CFTR
  Drug-Drug Interactions: 100
  WHO Essential: Yes — ATC M01AE01, analgesic/anti-inflammatory
  Formulations: IV 5 mg/mL; Oral 200/400/600 mg tablet; Liquid 100-200 mg/5 mL
  Dosage: 200-400 mg q6-8h; max 1200-2400 mg/day
  Contraindications: Active GI bleeding; severe renal impairment; third trimester pregnancy
  TGA ARTG: 10 registered products (BRUFEN 400mg, CALDOLOR IV, NUROFEN PLUS, etc.)

check_drug_interactions

Check drug-drug interactions for one drug or a specific pair. Returns interaction severity, mechanism, clinical effect, evidence level, and management recommendations for medication safety review.

query: "warfarin aspirin"
→ Severity: MAJOR; Mechanism: additive anticoagulant + antiplatelet effect;
  Clinical: increased bleeding risk; Management: avoid combination or monitor INR closely

check_adverse_events

Check FDA FAERS adverse-event records for a drug or active ingredient. Returns total reports, serious outcomes, death reports, top adverse reactions, and common patient age groups.

query: "isotretinoin"
→ Total reports: 12,847; Serious: 8,231; Deaths: 89; Top reactions: depression,
  inflammatory bowel disease, suicide attempt; Peak age: 15-25

search_pharma

Search across pharmaceutical regulatory and safety databases by keyword. Use for broad discovery across DrugBank, WHO Essential Medicines, TGA ARTG, FAERS, FDA NDI, drug interactions, and ChEMBL bioactivity.

query: "SSRI pregnancy" → matches across FAERS (birth defects), interactions, DrugBank warnings

Data

100% source-traceability: every record links to DrugBank, WHO, TGA, FDA FAERS, or ChEMBL primary sources.

Sources: DrugBank (open data), WHO Model List of Essential Medicines, Australian TGA ARTG, FDA FAERS (Adverse Event Reporting System), FDA New Dietary Ingredient notifications, ChEMBL (EMBL-EBI).

Quick Start

Claude Desktop / Claude Code

Add to your MCP config:

{
  "mcpServers": {
    "roots-pharma-regulatory": {
      "url": "https://pharma-mcp-server.rootsbybenda.workers.dev/sse"
    }
  }
}

Cursor / Windsurf / Zed

Use the Streamable HTTP endpoint:

https://pharma-mcp-server.rootsbybenda.workers.dev/mcp

Rate Limits

Every caller receives full data; a 60 requests/minute abuse-prevention limit applies per IP.

Built With

• Cloudflare Workers + Agents SDK
• Cloudflare D1 (SQLite at the edge)
• Durable Objects (session-scoped rate limiting)
• Model Context Protocol (MCP)

Who Built This

Roots by Benda — regulatory intelligence platform built by Shahar Ben-David with Claude. Pharmaceutical database assembled from primary sources across DrugBank, WHO, TGA, FDA, and ChEMBL.

• Website: rootsbybenda.com
• LinkedIn: Shahar Ben-David

License

MIT